This report takes a life course approach to examining inequalities in the drivers of health – known as the social determinants of health – in Hong Kong. The second report from the UCL and CUHK Institutes of Health Equity, it builds on the first, which examined inequalities in health and the social determinants of health and assessed the impacts of the COVID-19 pandemic on health and on the social determinants. This report begins with inequalities in maternity and during the early years, then continues into school age and working age, and finally into older age. There is a particular focus on mental health.